Your brain and fat are communicating with each other, scientists discover

“The implications of this finding are profound,” he also added.

“This is yet another example of how important sensory neurons are to health and disease in the human body,” says co-senior author and professor Ardem Patapoutian, Ph.D., who is also a Nobel laureate and a Howard Hughes Medical Institute investigator.

Before the recent study, the scientific world thought that adipose tissues were linked via the sympathetic nervous system. The research team had to create completely new imaging modalities to get the results of this research.

Two novel methods were used

Ye and his colleagues decided to use two novel methods to elucidate the study.

Firstly, the team used an imaging technique called HYBRiD to make mouse tissues transparent, allowing them to better track the paths of neurons as they snaked into adipose tissue.

The researchers discovered that nearly half of these neurons did not connect to the sympathetic nervous system but rather to the dorsal root ganglia, which is where all sensory neurons originate in the brain.

The team then used a second technique, which they called ROOT, for “retrograde vector optimized for organ tracing” to more thoroughly investigate the function of these neurons in adipose tissue.

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